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pH、ミント、刺激感

Sensation depends on pH, free nicotine, moisture, pouch material, salt, flavour and contact time.

pH & free-base nicotine

Higher pH usually increases free-base nicotine and can increase buccal absorption, but pH alone does not determine sensation.

Mint, menthol & cooling agents

Menthol activates receptors including TRPM8. Low concentrations may cool; higher concentrations can irritate or burn.

NIは1パウチに含まれるニコチン量を示し、吸収速度や体感強度を予測するものではありません。

  1. WHO technical report on nicotine pouches
  2. Nicotine permeation, pH and oral mucosa (2025)
  3. TRP channels, nicotine irritation and menthol
  4. Oral nicotine pouch ingredients and pH